| Date | Opponent | Location | Time/Result | |  | | Aug. 28, 2010 | @ Mars Hill College Live Stats Video | Mars Hill, NC | 30-36 L | Recap | Box | | Sep. 4, 2010 | @ Charleston Southern University Live Stats Video | North Charleston, SC | 31-41 L | Recap | Box | | Sep. 11, 2010 | @ Edward Waters College Video | Jacksonville, FL | 44-14 W | Recap | Box | | Sep. 18, 2010 | Lenoir-Rhyne University Live Stats Video | Tigerville, SC | 19-20 L | Recap | Box | | Sep. 25, 2010 | @ Presbyterian College Live Stats Video | Clinton, SC | 34-17 W | Recap | Box | | Oct. 2, 2010 | Ohio State Newark (Military Appreciation) Video | Tigerville, SC | 63-0 W | Recap | Box | | Oct. 7, 2010 | Wright State University Video | Tigerville, SC | 62-0 W | Recap | Box | | Oct. 16, 2010 | @ La Grange College Audio Live Stats | Lagrange, GA | 55-27 W | Recap | Box | | Oct. 23, 2010 | Edward Waters College (Homecoming) Video | Tigerville, SC | 42-0 W | Recap | Box | | Oct. 30, 2010 | @ Notre Dame College Audio Live Stats | South Euclid, OH | 21-14 W | Recap | Box | | Nov. 6, 2010 | @ UNC Pembroke Video | Pembroke, NC | 27-10 W | Recap | Box | | Nov. 20, 2010 | Campbellsville University (NCCAA Victory Bowl) Video | Tigerville, SC | 42-16 W | Recap | Box |
| | Record: 9-3 Home events are in bold.
All times are local. |
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